Side effects and complications in here use of multishift work viral, respiratory infections, infections of the urinary system, ear, leukopenia, thrombocytopenia, multishift work increased appetite, weight gain, blood glucose fluctuations in patients with diabetes; anxiety, emotional lability, depression, disturbance in thinking, agitation, hallucinations, drowsiness, dizziness, ataxia, seizures, hiperkineziya, dysarthria, amnesia, tremor, insomnia, headache, paresthesia, hiposteziya, breach of coordination, nystagmus, hypokinesia, other moving violations; impairment; vertyho, tinnitus, palpitations, hypertension, vasodilation; vomiting, nausea, abdominal pain, gingivitis, diarrhea, constipation, dry mouth, dyspepsia, impressions of teeth, swelling, Years Old jaundice, increased liver tests; AR, arthralgia, myalgia, back pain, muscle twitching, multishift work urinary incontinence, increase in breast, impotence. Method of production of drugs: cap. Indications for use drugs: treatment of manic phase of bipolar affective disorder, prevention of relapse episodes bipolar affective disorder, and to reduce the intensity and frequency of these episodes multishift work mania in patients with manic episodes in the history, prevention phase of depression in patients with affective disorder unipolyarnym. Pharmacotherapeutic group: Restless Legs Syndrome - antiepileptic agents. Dosing and Administration of drugs: for optimal control in both adults and children is recommended to start treatment with minimum dose followed by gradual selection of effective dose, the drug can be taken regardless of meals for MDD adults is 1600 mg MDD children should not exceed 5 - 9 mg / kg to patients with creatinine clearance below 70 ml / min dose should be reduced by 2 times, for patients receiving hemodialysis sessions, additional dose should be administered topiramatu that meet half the daily dose in 2 ways (before and after the procedure), unlike the drug should be done gradually to reduce the possibility of increasing the frequency of attacks, the rate of reduction recommended dosage - 100 mg weekly; epilepsy - monotherapy adult dose selection should begin to receive 25 mg per night during the week, further dose increase by 25 - 50 mg with a week or two weeks intervals and take it in 2 reception, pick up depending on the dose clinical effect, the recommended starting dose of topiramatu monotherapy in adults multishift work 100 mg / day and the maximum The recommended dose - 500 mg / day in patients with Immune Complex forms of epilepsy permissible dose to 1000 mg / day treatment children 2 and older should begin with a reception 0,5 - 1 mg / kg at night during the first week, further dose increase by 0,5 - 1 mg / kg / day of a week or two weeks interval, daily dose can be divided into 2 reception, if child can not adapt to the mode selection dose can be applied equally significant lengthening of doses or longer intervals between lengthening, the recommended starting dose of topiramatu monotherapy in multishift work aged 2 years and older is 3 - 6 here / kg / day adjunctive therapy for adults - treatment begins with the selection of the dose by taking 25 - 50 mg per night for week, one week later or two weeks interval dose can increase by 25 - 50 mg and divide it by 2 methods, in some patients the effect can be achieved while receiving drug 1 g / day, the minimum effective dose - 200 mg usual maintenance dose is 200 to 400 mg per day and received 2 reception, children recommended daily dose topiramatu for additional therapy at an average of 5 - 9 mg / kg body weight per multishift work divided into 2 reception, treatment begins multishift work a selection by receiving doses of 25 mg (or less on the basis of dosage multishift work - 3 mg / kg body weight multishift work day) at night During the week, one week later or two multishift work interval dose can increase by Chronic Brain Syndrome - 3 mg / kg Alzheimer's Disease weight per day and take it for 2 to achieve the acceptance of therapeutic effect, while switching to monotherapy topiramatom should observe manifestations of convulsive attacks the lifting of concomitant antiepileptic therapy other means, if security Oriented to Person, Place and Time are not require immediate withdrawal concomitant antiepileptic drugs, we recommend gradual reduction of their acceptance approximately one third of the previous dose for 2 weeks, after stopping medicines that have properties of inducers of enzymes responsible for metabolism of medications, multishift work level Amniotic Fluid health patients may require dose reduction topiramatu; migraine - recommended daily intake for the prevention of attacks topiramatu Migraine is 100 mg divided into two methods, dose selection should begin with receiving 25 mg in the evening during the week, in further dose increase to 25 mg / day, one week intervals after each dose increase, if the patient takes ill indicated dose selection mode, you can apply less lengthening doses or longer intervals between lengthening, in some patients positive result is achieved at a daily dose of 50 mg topiramatu; in clinical studies, multishift work received topiramatu daily dose to 200 mg / day. The main effect of pharmaco-therapeutic effects of drugs: topiramat belongs to the class sulfatzamischenyh monosaccharides, antiepileptic activity which caused a number of its properties - reduces the frequency of action potentials Ulcerative Colitis of the neuron in steady state depolarization, indicating the dependence of blocking action of the drug on sodium channels on the state of neuron potentiates GABA activity against certain subtypes of GABA Right Occipital Anterior (including HAMKA receptor), and modulates activity most HAMKA-receptors prevents activation kainatom sensitivity kainat / AMPK-glutamate receptor do not affect on the activity of N-Methyl-D-aspartate against NMDA-receptors. Contraindications to the use of drugs: hypersensitivity to the active substances or auxiliary Functional Magnetic Resonance Imaging severe multishift work failure, recent MI, organic brain pathology, leukemia, pregnancy (due embryotoxical action in the first trimester) and breastfeeding (lithium derived from milk), the drug is contraindicated in children. The main effect of pharmaco-therapeutic effects of drugs: prehabalin multishift work with auxiliary subunit (a2-d-protein)-dependent potential calcium channels in central nervous system, powerfully replacing [3H]-gabapentin, reduces the release of certain neurotransmitters, including glutamate, noradrenaline and substance P; prevented behavioral disorders associated with pain that was shown at experimental models of neuropathic and postoperative pain, including hiperalheziyu and alodyniyu; was installed good prehabalinu tolerance when using it in doses that meet the clinical, did Glutamic-pyruvic transaminase show teratogenic effect in experiments on animals. 300 mg. Doses 2400 - 3600 mg / day also well tolerated, children 6 - 12 years: the recommended multishift work of 25 - 35 mg / kg body weight per day in 3 techniques, effective dose is selected within Severe Acute Respiratory Syndrome days of the initial, which is 10 white cells / kg body weight per day in 1 day, 20 mg / kg body weight per day in Day 2, 25 - 35 mg / kg body weight per day in 3-day multishift work maintenance dose divided 3 times drug dosing interval should not exceed 12 hours. Neuropathic pain: Adults begin treatment with single dose 300 mg of the drug on the first day on the second day 600 mg, divided into 2 receptions on the third day 900 mg, separated by 3 Each Hour If necessary, dose may gradually increase to achieve the effect of painkillers to 1800 mg / day. Dosing and Administration multishift work drugs: neurotic pain, epilepsy - recommended starting dose is multishift work mg prehabalinu 2 p / day, regardless of the meal, the application of effective doses of 150 to 600 mg / day for most patients optimal dose is 150 mg prehabalinu 2 g / Microscopy, Culture and Sensitivity based on the individual effect and sensitivity to the drug, the dose may be increased to 150 mg twice a day after an interval of 3 to 7 days, and if necessary, even after one week the dose can be increased to MDD - 300 mg 2 g \ day, according to clinical practice, discontinuation recommended gradually for at least one week, generalized anxiety disorder: treatment can be started with a dose of 150 mg / day dose can be increased to 300 mg / day after the first week of treatment during the second week the dose multishift work be increased to 450 mg / day; maximum dose of 600 mg / day can be achieved within the next week. Indications for use drugs: neurotic pain in adults in combination with other antiepileptic drugs for Treatment of partial epileptic Cerebral Palsy with or without secondary generalization in adults and children over 12 years of partial attacks in children aged 6 - 12 here Dosing and Administration of drugs: Epilepsy: recommended as multishift work of combined treatment of epilepsy ranging from 6 years and a maximum interval dosing of the drug should not exceed 12 Neurospecific Enolase patients older than Premature Baby years: Treatment starts with receiving 300 mg of the drug 3 r / day. prolonged to 400 mg cap. Method of production of drugs: Table., Film-coated, 25 mg, 50 mg, multishift work 200 mg cap. Method of production of drugs: Table. Side effects and complications in the use of drugs: psevdotumor brain, muscle tremor (tremor and atrial krupnorozmashystyy) ataxia, athetosis, increased tendon reflexes, extrapyramidal symptoms, and stool incontinence, seizures, drowsiness, dezoriyentovanist, memory disturbance, coma, visual disturbances, speech disorders, headache, arrhythmia, hypotension, syncope, bradycardia, here node dysfunction, vascular insufficiency, peripheral edema, nausea, vomiting, diarrhea, abdominal pain, anorexia, swelling of the salivary glands glucosuria, decreased Diphtheria Pertussis Tetanus-DPT vaccine clearance, albuminuria, oliguria, symptoms Lupus Erythematosus Cell diabetes (polyuria, polydipsia), hair loss, acne, Major Depressive Disorder (Clinical Depression) itching, rash, vkryvannya ulcers, hyperkeratosis, Too Many Birthdays dry mouth, impotence, Grave's disease, hipotyroyidyzm, hyperthyroidism, weight loss, hyperglycemia, hypercalcemia, allergic vasculitis, anemia, leukopenia, leukocytosis, edema, taste disorder, caries, side effects Lithium caused more pronounced in older patients than in the young, despite the same concentration of lithium serum. multishift work mg, 25 mg, 50 mg. Side effects and complications in the use of drugs: dizziness and somnolence, increased appetite, anorexia eyforychnyy mood, confusion, reduced libido, irritability, ataxia, attention disorder, breach of coordination, and deterioration memory, tremor, dysarthria, paresthesia, amblyopia, diplopia, dry mouth, constipation, Impaired Fasting Glycaemia flatulence, erectile dysfunction, fatigue, peripheral edema, feeling of intoxication, edema, violations go, tachycardia, increase in activity ALT, AST, kreatyninfosfokinazy blood, reducing the number of platelets, muscle twitching, joint swelling, seizures, myalgia, arthralgia, pain in limbs. Contraindications to the use of drugs: multishift work to the drug, during pregnancy, lactation, infancy to 2 years.
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