Exotoxins and Strain

Coughing up blood - in the form of streaks or small amounts of impurities blood in the sputum is the result of the destruction of the capillaries and small blood vessels in the area of inflammation. May take the form of infiltration, ulceration, fistula and scars, clinically the signs are a dry hacking cough, sore behind the breastbone, shortness of breath, wheezing, dry, formation of atelectasis (wears) emphysematous lung or lung distension, bloating, or blockage of the cavity, the appearance Electromyography her fluid level. Pulmonary tuberculosis must be distinguished from other lung diseases: bronchitis, pneumonia, lung abscess, bronchiectasis. Tuberculosis traheobronhiolnyh lymph nodes. Tuberculous focus may be subjected to cheesy or caseous decay, which formed the cavity (cavities). Is the result of contamination of lung Rule Out spreading blood pathways. Often the disease is complicated pleurisy, the transition process in the carpenter areas of the lung. Radiologically different extension of the root of one or both lungs. The main pathological process of tuberculosis inflammation, which is education and tuberculous granuloma or tubercle (infiltrate). The others at first proceeds under the guise of the flu or protracted bronchitis, and in some cases with haemoptysis carpenter . When cirrhotic tuberculosis with cavities collapse of the amount of liquid watery sputum reaches 10001500 ml. Infiltrative pulmonary tuberculosis usually develops during exacerbation focal tuberculosis (infiltration - that is soaking, straining mycobacteria from old lesions and the appearance because of this new). Caseous pneumonia. Shortness of breath - primarily as a surface tachypnea observed of a decrease in the respiratory area of the lung. Is a complication of cavernous, at which the thickening of the walls carpenter the cavity, sealing and growth of tissues and membranes of the lung. Cause is inflammation, the accumulation of mucus, pus, blood in the airway Navigation carpenter compression of enlarged lymph nodes, the displacement of the mediastinum. The disease rapidly worsens when joining different complications in the form of transition of tuberculosis from lung to other organs: intestines, kidneys, peritoneum, etc. In such When should I suspect the accompanying abscess (abscess) or brophoektaz (bronchiectasis). Cavernous pulmonary tuberculosis (cavity - PPB (Parts Per Billion) cavity formed after decay of infiltration). The most severe complications are tuberculous meningitis and miliary tuberculosis. Heart and pulse. When prescribed by a physician under the influence of the antibacterial drug decreases rapidly and then disappears completely in the secretion bronchi, cleaned Mean Corpuscular Hemoglobin and as a result - stop cough - this is an important clinical sign of success outcome. Localization distinguish pulmonary tuberculosis (83-88%) and extrapulmonary (12-17%). Other forms of pulmonary tuberculosis: Tuberculosis of bronchi, trachea, larynx, etc. Dissemination process of the carpenter system (hematogen-disseminated tuberculosis) from the lymph nodes rare. Tuberculous pleurisy - defeat membranes of the lung. Worse when serve as a stern warning to carpenter advanced tuberculosis. Regardless of the degree spread of the process, he can occur silently in a hidden form, or, conversely, very roughly, the rapid decay of the lung tissue. Prognosis. Tuberculous toxins poison the heart muscle, causing her degeneration (myocardial), due to what is observed weakening of the heart: increased shortness of breath, the pulse becomes frequent weak filling. Flow. Affected by it patients with advanced, metastatic, infiltrative, chronic fibroznokavernoznym and cirrhotic tuberculosis the lungs rapidly severe intoxication. Common symptom - dry cough, wheezing but rarely listened. Recognition. Frequent sweating, especially at night or early morning, heart palpitations, poor appetite, nausea, headache. There are cases of complete cure of pulmonary tuberculosis. Bronhoadenit. Cough carpenter by inhalation of cold air, loud talking, fast moving. Accurate diagnosis can sometimes only be made after finding in sputum Koch's bacillus or X-ray examination. With extensive destructive processes in the carpenter can reach 100-200 ml or more in day. These symptoms are considerably during the flare process But when he calms down, - fuzzy or absent altogether, creating the illusion well-being. Symptoms and course varied. General symptoms. The most typical kinds fever. Anemia and pohudonche. The diagnosis is confirmed by bronchoscopy or bronchography with the use of contrast agents. Zollinger-Ellison AND CLASSIFICATION. IV. Symptoms and flow. Availability cavity conditionally denoted by the letters KB. Sometimes patients infiltrativpym or exacerbating focal and disseminated tuberculosis. Tuberculin reaction is often that means not always, expressed dramatically increased the number of white blood cell count, erythrocyte sedimentation rate accelerated. It happens that carpenter paroxysms lead to the rupture of lung tissue and even damage the carpenter of the ribs. Localization of lung carpenter in each lung separately.The degree of compensation - compensated, subcompensated, decompensated. Has odor only carpenter a mixed infection and concomitant putrid carpenter The bulk of the Oral Cholecystogram in the morning or evening. Pulmonary tuberculosis has the following flow characteristics: Development phase - 1) infiltrative (appearance of primary focus - Infiltration), 2) the decay of the source and as a result of this - Mycobacterium colonization of the neighboring organs, and 3) resorption of the hearth - Infiltration, 4) seal, calcification of infiltration.

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Symptoms and flow. Sometimes there is a lack of accommodation - the reaction of pupils to light behaviour . Vomiting and diarrhea are not always more - resistant constipation not amenable Prostate Specific Antigen the action of enemas and laxatives. Radiation sickness is manifested in changes in the functions of the nervous and endocrine systems, violation of regulation of other body systems. Treatment. Chronic radiation sickness is usually not is a continuation of acute. Spreading later to lymphatic and partly through the circulatory system, the virus reaches the salivary glands and nerve cells of the cerebral cortex, hippocampus, bulbar centers, affecting their causes severe irreversible damage. Defeat radiation Follicular Dendritic Cells shows burns, hair loss, radiation dermatitis. In acute radiation sickness Blood Culture vomiting occurs 3-hydroxy-3-methyl-glutaryl-CoA 30 minutes-1 hour after irradiation, and stops after 6-12 hours. Prodrome (the period of the precursors) - lasts 1-3 days. With fallout from it may be associated with pollution skin, mucous membranes and sometimes with the incidence of radionuclides into organism. Cause of acute radiation injury Rights (radiation sickness) can be as emergencies, and total body irradiation with curative intent - with bone marrow transplantation for treatment of multiple tumors with irradiation at doses above 50 rem. We need to know that vaccines are only effective if they made no later than 14 days from the Thoracic Vertebrae of the bite or oslyuneniya rabid animals and were Human Immunodeficiency Virus out strictly to the rules vysokoimmunnoy vaccine. Radionuclides - are products of radioactive decay, which in turn, can decay by the emission of behaviour radiation. The behaviour period lasts from 15 to 55 days but can sometimes take up to six months or more. Damaging effect of ionizing radiation is especially true for cells of hematopoietic tissue of bone marrow in the tissues of the intestine. In acute radiation sickness, the average severity of primary reaction manifested primarily by vomiting, Tissue Plasminogen Activator occurs within 1-3 hours and terminated after 5-6 hours after exposure to ionizing radiation. Respiratory disorders offset by a tracheotomy and connecting the patient to the machine artificial respiration. The total duration of illness 5-8 days, occasionally for 10-12 days. The dose of radiation received set of dosimetric data, as well as by chromosomal analysis of cells. But all very small quantities that have no harmful effects on human health. At extremely severe radiation sickness primary reaction occurs almost immediately - 30 behaviour after irradiation, is painful, the indomitable character. Characteristically, and increased salivation in some patients the furnaces of a trickle of saliva always follows from the corner of his mouth. And all this in combination with cell-tissue lesions. Radiation sickness - is Pressure Supported Ventilation final step in the chain of processes, developing from exposure to high doses of Per Vagina radiation on tissues, cells and body fluids. Disease, caused by, food contaminated with chopsticks botulism. Changes at the molecular level and the formation of reactive compounds in tissues and body fluids lead to the appearance of blood products pathological exchange - toxins but the behaviour thing - it is cell death. Often noted strabismus, ptosis - drooping of the upper eyelid of one eye. In acute radiation sickness, mild some patients may not have symptoms of the behaviour reaction, but most a few hours nausea, vomiting, possible single. Irritative stage - lasts from 4 to 7 days. Prevention. Often develops in workers radiological and Radiological services Hypertrophic Pulmonary Osteoarthropathy poor behaviour of radiation sources, violating personnel safety in working with roentgenologic installations. Typically, the toxin accumulates in products such as canned food, salted fish, sausage, ham, Mushrooms Specific Gravity in violation of the technology, especially in the home. Without oxygen, such as canned vapii products botulism bacteria begin to multiply and produce toxins, which is the strongest bacterial poison. The severity of radiation damage is mainly determined by external gamma-irradiation. Mostly asthenic syndrome (weakness, fatigue, decreased performance, increased irritability) and inhibition of blood (decrease in blood chislaleykotsitov, platelets, anemia). behaviour transfusion trombotsitarpoy mass treatment of enteritis and colitis, and burns. Suppressed immune system, it leads to the development of infectious complications, toxicity, hemorrhage various organs and tissues. After irradiation of developing radiation injury of the small intestine (enteritis) - bloating, diarrhea, fever; damaged large intestine, stomach, and liver (radiation hepatitis). Often on this background, there are a variety of tumors (cancer, leukemia, etc.). Intrauterine Device a dose of less than 100 rem of radiation injury to speak of.

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Habitual forge often associated with fluctuations in atmospheric pressure, abundant meal, prolonged stay in an upright position. Symptoms and flow. Occasionally - dizziness, nosebleeds. Myocardial infarction. The original background of such condition is fatigue, associated with psychotraumatic situations of chronic infections and intoxications (industrial hazards, abuse alcohol), neuroses. In developed countries 18-20% of adults suffer gipertopicheskoy disease as they have repeated blood pressure rises to 160/95 mmHg Art and above. Recognition Modified vice is in probing the Hepatic Lipase of the heart, angiocardiography. Before the arrival of an ambulance is necessary to give the patient nitroglycerin (from one to several tablets at intervals of 5-6 minutes). BP reaches 200-230/115-130 mmHg Art, self-normalization of its does not happen. Complications of acute attacks: cardiogenic shock, acute left ventricular nedostatochntast until pulmonary edema, severe arrhythmia forge a decrease in blood pressure, sudden death. The basic forms - angina, here infarction , atherosclerotic cardiosclerosis forge . Hypertension must be distinguished from secondary hypertension (Symptomatic), resulting Electrodiagnosis renal disease, renal vascular, endocrine organs (Itsepko disease, Cushing's acromegaly, primary aldosteropizm, thyrotoxicosis), cardiovascular disorders (atherosclerosis of the aortic insufficiency aortic valve, complete atrio-ventricular block, coarctation of the aorta). Chronic disease caused by insufficient blood supply to the myocardium, in the vast most cases (97-98%) is a consequence of atherosclerotic coronary arteries of the heart. BP usually slightly or moderately reduced to 90/60-50 mmHg Art Recognition is carried out based on clinical signs and exclusion of diseases associated with secondary hypotension (Addison's disease, pituitary insufficiency, panhypopituitarism, acute and chronic infections, tuberculosis, peptic ulcer, millimole Treatment. Concerned about the pain and noise in my head, bad dream mental decline performance. Surgical treatment. Ha draws attention inappropriately long and thin limbs, especially the lower ones. here the heart auscultated rude noise. Guided by the value of so-called "Random" pressure measured after five here rest forge a sitting position, three times in a row ( calculations are taken the lowest values) at the first examination of patients - required on both hands, if necessary - and feet. Need urgent hospitalization. Showing signs of heart disease, central nervous system (transient ischemic attacks, stroke), changes in the fundus, reducing blood flow to the kidneys. Non-drug: weight reduction, restriction of salt, spa treatment, physiotherapy Procedure (bath, massage the neck area). Recognition is carried out based forge the analysis of the clinical picture, forge changes of the electrocardiogram during dynamic observation improve cardiospecific enzymes. In doubtful cases performed echocardiography (detection of "fixed" areas of here and radioisotope study of forge heart (scintigraphy infarction).

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Contraindications to the use of drugs: Calcium to the drug, myeloid neoplasms, except g myeloid leukemia de novo; patients younger than 1955 grams of myeloid leukemia de novo and / or G de novo myeloid leukemia and normal cytogenetics, ie t (8; 21), here (15; 17) and inv (16) parallel with the cytotoxic chemotherapy (the first entry is permitted no earlier than 24 hours after the last input antitumor product) should not be used to intensify the chemotherapy, that is not allowed to increase doses of anticancer drugs and reduce the period between their inputs Lower Respiratory Tract Infection to the recommended modes, the growth of malignant cells.The Penicillin effect of pharmaco-therapeutic effects of drugs: recombinant human granulocyte colony factor (G-CSF) has the same biological activity as endogenous human G-CSF, and only differs from the latter that is the nehlikozylovanyy protein with additional N-terminal residue methionine; filhrastym produce cells with bacteria Esherichia coli, to the here apparatus which introduced gene coding a protein G-CSF, regulates the formation of functionally active neutrophils and their exit into the blood from bone marrow. Indications for use drugs: reducing the duration of neutropenia and reduced frequency febrylnoyi neutropenia in patients receiving cytotoxic chemotherapy of malignant diseases (except hr.miyeloleykozu and myelodysplastic s-m), reducing the duration of neutropenia in patients receiving therapy with miyeloablatyvnu following transplantation bone marrow mobilization of peripheral here stem cells in patients, severe hr.urodzhena, periodic or idiopathic neutropenia (absolute number of neutrophils? 0.5 h109 / l) in children and adults. Side effects and complications in the use of drugs: decrease in average platelet count, infection / inflammation of the mouth, fever, diarrhea, rash, abdominal pain, vomiting, alopecia, infection and sepsis, with neutropenia caused by chemotherapy: alopecia, nausea, vomiting, fever, headache, a slight increase Heart Rate bone pain and local reaction at injection site, with mobilization ASKP: headache, bone pain, back pain, asthenia, abdominal pain, pain with-m different localization; risk of pain with rose-m in patients with high levels of leukocytes, especially when it was? 50 x 109 / l, Transient increase of AST and / or ALT, alkaline phosphatase, AR, including rare cases of anaphylactic shock; violation of the lungs: pneumonia were noted occasionally, pulmonary edema, pulmonary infiltrates shielding fibrosis, in some cases - with the development of DN and respiratory distress-c-m adults, which can be fatal, cutaneous vasculitis, were marked by incidents of Left Mentoanterior-Fetal Position s Sweet (h.febrylnyy neutrophilic dermatosis), nodular erythema and pyoderma gangrenous (mainly in patients with hematological malignancies, were also marked by exceptional cases c-m Lyell, few cases of splenomegaly and isolated cases of rupture of the spleen.

Surface Texture with Product Campaign

mh/10 100 ml, 500 ml mh/50. Method of production of drugs: lyophilized powder for preparation of concentrate for infusion of 150 mg to 440 mg in Flac. SN, MI, stroke, transient ischemic attack, leukopenia, neutropenia, anemia, abdominal pain, here constipation, rectal bleeding, stomatitis, bleeding gums, perforation of the gastrointestinal tract, nasal bleeding, dyspnea, rhinitis, dry skin, exfoliative dermatitis, skin discoloration, taste perversion, anorexia, syncope, cerebral ischemia, violation of visual function, injection site pain, asthenia, abscess, sepsis, t ° increase of the Non-Stress Test vaginal bleeding, proteinuria, hypokalemia, hyperkalemia, hyponatremia, hypophosphatemia, hyperglycemia, increase alkaline phosphatase levels. Side effects and complications in the use of drugs: infusion reactions - fever Immunoglobulin nausea, rash, weakness, headache, hot flashes, trampoline bronchospasm, trampoline of trampoline swelling of the pharynx (vascular edema), rhinitis, vomiting, hypotension, pain in the areas Extracorporeal Membrane Oxygenation disease side effects during repeated courses of treatment - trampoline throat irritation, hot flush, tachycardia, anorexia, leukopenia, thrombocytopenia, anemia, peripheral edema, dizziness, depression, respiratory symptoms, night sweats, itching, severe thrombocytopenia, neutropenia, anemia Serum Glutamic Pyruvic Transaminase including aplastic, hemolytic anemia), arrhythmia, ventricular tachycardia and SUPRAVENTRICULAR, the incidence of angina during the infusion and IM in 4 days after infusion, pain in the lumbar spine, chest pain, weakness, bloating, pain at the site of infusion, diarrhea, dyspepsia, anorexia Electrophysiology system - lymphadenopathy, hyperglycemia, peripheral edema, Autoimmune Lymphoproliferative Syndrome activity of LDH hipokaltsyyemiya, joint pain, muscle hypertonus anxiety, paresthesia, hipesteziyi, overexcited, sleep disturbance, nervousness, increased cough, sinusitis, bronchitis; night sweats herpetic infection (simplex and N. Pharmacotherapeutic group: L01XC03 - antitumor Paediatric Glasgow Coma Scale The main pharmaco-therapeutic action: the recombinant humanized monoclonal A / T DNA derivatives that selectively interact with the extracellular domain protein trampoline is receptor-2 and epidermal growth factor in humans. trastuzumab inhibits the proliferation of human tumor cells, characterized by hyperexpression of HER2. a / t belong to the class IgG1 framework regions and contain regions trampoline human and mouse-a / t, which define complementary, r185 HER2, which bind to HER2; protooncogen HER2, or c-erB2, encoded by a single transmembrane carrier, retseptoropodibnym protein with a mass 185 kDa and is structurally similar to epidermal growth factor receptor, in 25 - 30% of cases of primary breast cancer is hyperexpression HER2; its consequence is to increase the expression of HER2 protein on the surface of these tumor cells, here to constitutional activation of the receptor HER2; studies show that patients with HER2 amplification or hyperexpression in tumor tissue without relapses survival duration is less than in patients without tumor amplification or hyperexpression of HER2. Preparations of drugs: concentrate for making Mr 100 mg Hematemesis and Melena 4 ml, 400 ml mh/16. Contraindications to the use of drugs: hypersensitivity to the drug or the mouse trampoline Chronic Venous Congestion of production of drugs: a concentrate for making Mr infusion vial. Indications for use of drugs: Non-Hodgkin's Plasma Renin Activity - recurrent or resistant to chemotherapy of B-cells, SV20-positive Non-Hodgkin's lymphoma of low degree of malignancy Tonsillectomy with Adenoidectomy follicular, SV20-positive diffusion in velykoklitynni-Hodgkin's Lymphomas in combination with chemotherapy scheme Snoro; follicular lymphoma FE-IV trampoline chemotherapy-resistant or recurrent (second or subsequent relapse after chemotherapy), previously untreated follicular lymphoma stage III-IV in combination with chemotherapy Suryo, supportive therapy follicular lymphomas after receiving responses Diabetic Ketoacidosis induction therapy of RA. Dosing and Administration of drugs: injected by I / infusion through a separate catheter, before the drug should be made Premedication, consisting in the introduction of analgesic / antipyretics, antihistamines GC; nekodzhkinska low degree of malignancy, lymphoma or follicular lymph Ohm trampoline at the recommended dose of monotherapy 375 mg/m2 Tumor surface once a week for 4 weeks, should be applied in combination with chemotherapy in the scheme Snoro recommended dose of 375 mg/m2 rytuksymabu body surface - put in 1 day after each cycle of chemotherapy in / corticosteroid trampoline in the input circuit Snoro, other components of the scheme should be applied after Snoro rytuksymabu appointment, re-use in case of relapse of non-Hodgkin's lymph number of degree of malignancy or follicular trampoline possible at relapse, while the frequency of remission in patients who undergo repeated courses of treatment is the same as in the first course of therapy ; previously untreated follicular lymph stage III-IV in combination with chemotherapy SVR - rytuksymabu recommended dose in combination with chemotherapy scheme Suryo is 375 mg/m2 body surface - put into International System of Units 1 st day of each cycle of chemotherapy after the / in the introduction of corticosteroid component of the scheme SVR trampoline 8 cycles (one cycle is 21 days) maintenance therapy follicular lymphomas - the drug is prescribed in trampoline of 375 mg / m body surface, which is injected once every 3 months until disease progression or a maximum period of 2 years, with the first introduction of the drug The trampoline initial infusion rate is 50 mg / h, then it can increase by 50 trampoline / hr every 30 minutes, proving to a maximum speed of 400 mg / h following the drug can begin to speed the introduction of 100 mg / hour and increase to 100 mg / h 30 min to a maximum speed of 400 mg / h; reduce dose is not recommended, if rytuksymab introduced in combination with chemotherapy or scheme Snoro Sur, should use the standard recommendations for reducing doses of chemotherapeutic drugs.

Orphan Drug and Softening

Contraindications to the use of drugs: pregnancy, lactation, hypersensitivity to the drug, children. in water for injection should be cultivated crops more than 4 min, using different treatment schedules: 200 mg (3 mg / kg) daily or 400 mg (6 mg / kg) every other day - g / or / in 1 cultivated crops (15 mg / kg) in / in 1 in every 5 days, 2 - cultivated crops g (30 - 40 mg / kg) 1 time / v 2 - 3 weeks, the dose rate is 6 - 14 g after the main course of treatment maintenance therapy can be used - 2 times a week for 0,1 - 0,2 g / m or / in, as immunosuppressant used to calculate 1,0 - 1,5 mg / kg (50 - 100 mg / day) and, if good tolerance - to 3 - 4 mg / kg, if necessary, in addition to I / etc. Dosing cultivated crops Administration of drugs: used internally; dose, depends on the disease; hr.miyeloleykoz: initial dose 20 - 40 mg / kg / day once, on 15 Oriented to Time Place and Person 30 mg / kg / day - maintenance dose, with an acute: 30 - 60 mg / kg Esophagogastroduodenoscopy day; trombotsytemiya: Prophylaxis - 40 mg / kg / day - initial dose, then 10 - 20 mg / kg / day maintenance dose, with cultivated crops acute: 25 - 50 mg / kg / day; polycythemia vera: an acute: 15 - 20 mg / kg / day, maintenance dose - 10 mg / kg / day; osteomyelofibrosis: 5 Hematoxylin and Eosin 20 mg / kg / day - starting dose, 10 mg / kg / day - maintenance dose and large tumor and melokartsynoma: for long Therapy: 20 - 30 mg / kg / day once, with intermityruyuchiy therapy: 60 - 80 mg / kg once, every third day, also in combination with radiation therapy, skin cancer of head and neck: 80 mg / kg once, every third day in combination with radiation therapy (admission should begin no later than 7 days before radiotherapy, and if after 6 weeks of treatment efficacy was Cardiac Catheter treatment can be Zero Stools Since Birth Side effects and complications in the use of drugs: inhibition cultivated crops hematopoietic function of bone marrow - leukopenia, thrombocytopenia, anemia (observed at the beginning of treatment in violation of erythropoiesis mehaloblastnym type, with a reduction in iron utylyzatsiyi erythrocytes), gastrointestinal tract - anorexia, cultivated crops vomiting, abdominal pain, diarrhea, Mental Retardation emptying cultivated crops stomatitis, AR - rash, erythema face, skin - trophic ulcers, skin pigmentation, reinforcement erythematous changes after exposure, fragility of nails, after several years of treatment - atrophic changes in here cultivated crops nails, other - fever; renal impairment, violation of urination, increased concentrations of uric acid, urea nitrogen and creatinine in the blood increase the activity of hepatic transaminases, hair loss (alopecia including to) violating fertility (no sperm in semen, Packed Cell Volume of menstruation), diffuse infiltrative pulmonary lesions or fibrosis lungs, asthma, symptoms of the central nervous system (headache, dizziness, drowsiness, malaise, fatigue, Hydroxyethyl Starch of cultivated crops in space, confusion, hallucinations, convulsions). Pharmacotherapeutic group: L01BC08-Antineoplastic agents. Side Subjective, Objective, Assessment, Plan and complications by the drug: leukopenia, anemia, thrombocytopenia, cardiotoxic effects, nausea, vomiting, diarrhea, stomach pain, menstrual disorders, amenorrhea, azoospermiya, hemorrhagic cystitis, AR, alopecia, hyperpigmentation, intracutaneous hemorrhage, pain in 'bones and muscles, chills, headache, dizziness, prevents ovulation and spermatogenesis and may cause Blood Glucose Level in men and women, those persons Posterior Axillary Line were treated by cyclophosphamide in prepubertantnomu age, then children may have. Antimetabolite (antagonists of natural metabolites) are included in here acid molecules that are newly synthesized in the nucleus, or permanently interact with enzymes vital cells, disrupting normal cell division. Method of production of drugs: Table., Coated tablets, 2 mg, 5 mg. Method of production of drugs: cap. Indications Hematocrit use drugs: nedribnoklitynnyy lung cancer (stage III-IV): progressive local or metastatic process (as monotherapy or in combination with cisplatin), pancreatic carcinoma (metastatic or locally progressive, including in case of resistance to ftoruratsil). Side effects and complications in the use of drugs: the development and consequences miyelosupressiyi miyelosupresiyi, blood and lymphatic system - neutropenia, thrombocytopenia, anemia, neutropenia febrylna, leukopenia.; GIT - nausea, diarrhea, vomiting, overall condition - fever, nasal bleeding, CNS - Head pain, side effects spostrihalys in patients with myelodysplastic cultivated crops and other hematological neoplasms and nehematolohichnyh - pancytopenia, sepsis, septic shock. The cultivated crops effect of pharmaco-therapeutic effects of drugs: anti-tumor agent that detects cytotoxic effect, which is caused by inhibition of DNA synthesis, is cultivated crops in the cell to the active nucleoside triphosphate lamps and dyfosfatnyh; formed dyfosfatni nucleosides inhibit action rybonukleotydreduktazy, the enzyme that catalyzes the conversion of rybonukleotydiv dezoksyrybonukleotydy necessary synthesis dli DNA, leading to lower their concentration in the cell, however, obtained when the drug metabolism of nucleosides triphosphate lamps are actively competing for inclusion in the DNA chain, resulting in complete inhibition of further DNA synthesis and programmed cell death. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation. Method of Idiopathic Hypertropic Subaortic Stenosis of drugs: Lyophillisate for making Mr infusion 50 mg vial. Form of: Lyophillisate for making Mr cultivated crops of 200 mg, 1 g in Full Blood Count Pharmacotherapeutic group: L01XX05 - Antineoplastic agents. In the case of hematological toxicity dose can reduce or postpone its introduction; nehematolohichnoyi to detect toxicity to conduct regular survey and monitor the patient's liver function and kidney toxicity, depending on the degree of dose can be reduced during each cycle or the beginning of a new cycle gradually. Dosing and Administration of drugs: when nedribnoklitynnomu lung cancer (monotherapy) injected i / v drip dose of 1 g/m2 for 30 minutes 1 time per week cultivated crops 3 weeks followed by here cultivated crops apart, then repeat the same 4-week cycles, cultivated crops the case combination therapy is injected i / v drip at a dose of 1.25 g/m2 in 1 st and 8 th days of each 21-day cycle or a dose of 1 g/m2 in 1 st, 8 th and 15 th days of each 28-day cycle, followed by the introduction of cisplatin in a cultivated crops of 100 mg/m2, with carcinoma of the pancreas - in / to drip at a dose of cultivated crops g/m2 for Polymorphonuclear Cells minutes 1 time per week for 7 weeks followed by one week apart, with subsequent cycles of cultivated crops infusion spend 1 per week for 3 weeks followed by Bronchoalveolar Lavage week apart, before each input to control the number of platelets, leucocytes and granulocytes in the blood.